The FSB of a CPU is independent of the memory clock served by the memory controller (north bridge). So there's no problem with compatibility. The best performanc tends to be when memory clock and FSB are in sync, but it's not a big deal.
I dunno, there's no point. It's already running at 3GHz; the performance increase you'll see is microscopic. If you do this, however, you should get DDR2 rated at 1066, so you can increase memory clock, too. But even that's not necessary. Most BIOSes in higher end boards let you run the memory completely out of sync with the FSB.
I just built a system for a friend with a P5N-E. It seems to be a sweet board.


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